Actimmune® (interferon gamma-1b) is a bioengineered interferon gamma, a naturally occurring human protein that acts as a biologic response modifier that stimulates the immune system and has direct effect on various cells in the body.

Actimmune is indicated for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD). Actimmune is also indicated for delaying time to disease progression in patients with severe, malignant osteopetrosis.

The most common adverse events observed in patients with CGD were flu-like symptoms (i.e., headache, fatigue, fever, myalgia, and rigors). Similar safety data were observed in patients with severe malignant osteopetrosis. Please refer to the Actimmune package insert for more complete safety and prescribing information.